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University of Pittsburgh
NIH Mark
Pitt-TraCe is funded by the National Center for Advancing Translational Sciences.
Award Number 1U2CTR004863-01

News

  • Title
    Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective
    Date
    Jul 31, 2025
    Authors
    Mark T Miedel, Mark E Schurdak, Andrew M Stern, Alejandro Soto-Gutierrez, Eric von Strobl, Jaideep Behari, D Lansing Taylor
    Citation
    Semin Liver Dis. 2025 Jul 23:10.1055/a-2649-1560. doi: 10.1055/a-2649-1560
    Journal
    Link to Journal
  • Title
    Validation of microphysiological systems for interpreting patient heterogeneity requires robust reproducibility analytics and experimental metadata
    Date
    Apr 14, 2025
    Authors
    Mark T Miedel, Mahboubeh Varmazyad, Mengying Xia, Maria Mori Brooks, Dillon C Gavlock, Celeste Reese, Jaideep Behari, Alejandro Soto-Gutierrez, Albert Gough, D Lansing Taylor, Mark E Schurdak
    Citation
    Cell Rep Methods . 2025 Apr 21;5(4):101028. doi: 10.1016/j.crmeth.2025.101028.
    Journal
    Link to Journal
  • Dr. Taylor recently discussed organ-on-a-chip technology and the Pitt-TraCe qualification program on the Behind Our Science podcast. – July 30, 2025 Episode 29- Organ-on-a-Chip: an afternoon with Dr. Lans Taylor

  • A letter of intent for the LAMPS as a DDT to establish the hepatotoxicity of drug candidates in patients with MASLD and assist in the determination of drug candidate dosing in clinical trials when patients with MASLD are included has been submitted and determined to be reviewable by the CDER ISTAND pilot program for qualification. […]

  • The letter of intent for the LAMPS as a DDT to establish the hepatic clearance of drug candidates in patients with MASLD and assist in the determination of drug candidate dosing in clinical trials when patients with MASLD are included has been accepted into the CDER ISTAND pilot program for qualification. – June 23, 2025.

  • Dr. Mark Miedel presented Patient-specific Microphysiology Systems as an Innovative Precision Medicine Platform for Metabolic-Dysfunction Associated Steatotic Liver Disease at the 23rd NIH MPS World Summit being held in Seattle, WA June 9-14, 2024

  • Dr. Mark Schurdak presented Qualification of Patient-derived Biomimetic Liver MPS as Drug Development Tools for Drug Metabolism, Toxicity, Drug Efficacy Testing, and Clinical Trial Cohort Selection  at the 23rd NIH MPS World Summit being held in Seattle, Washington June 9-14, 2024

  • Mengying (Summer) Xia presented a poster Toward Precision Medicine for Metabolic Dysfunction-Associated Steatotic Liver Disease Comparing Wildtype and a High-Risk PNPLA3 Variant in a Human Biomimetic Liver Microphysiology System at the 23rd NIH MPS World Summit being held in Seattle, Washington June 9-14, 2024

  • Dr. Mark Schurdak presented a talk “’Show Me the Reproducibility!’ Data Management Best Practices to Enhance Confidence in Complex MPS Models and Their Predictions” at the Society of Toxicology Annual Meeting held in Salt Lake City, Utah March 10-14, 2024.

  • Title
    Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy.
    Date
    April 30, 2024
    Authors
    Xia M, Varmazyad M, Pla-Palacín I, Gavlock DC, DeBiasio R, LaRocca G, Reese C, Florentino RM, Faccioli LAP, Brown JA, Vernetti LA, Schurdak M, Stern AM, Gough A, Behari J, Soto-Gutierrez A, Taylor DL and Miedel MT
    Citation
    Cell Dev. Biol. 12:1423936. doi: 10.3389/fcell.2024.1423936
    Journal
    Link to Journal
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