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Pitt-TraCe is funded by the National Center for Advancing Translational Sciences.
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Category: Publications

  • Perspective: Digital & Biomimetic Twins for Precision Medicine

    Category
    Title
    Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective
    Date
    Jul 31, 2025
    Authors
    Mark T Miedel, Mark E Schurdak, Andrew M Stern, Alejandro Soto-Gutierrez, Eric von Strobl, Jaideep Behari, D Lansing Taylor
    Citation
    Semin Liver Dis. 2025 Jul 23:10.1055/a-2649-1560. doi: 10.1055/a-2649-1560
    Journal
    Link to Journal

  • Reproducibility Analysis of MPS

    Category
    Title
    Validation of microphysiological systems for interpreting patient heterogeneity requires robust reproducibility analytics and experimental metadata
    Date
    Apr 14, 2025
    Authors
    Mark T Miedel, Mahboubeh Varmazyad, Mengying Xia, Maria Mori Brooks, Dillon C Gavlock, Celeste Reese, Jaideep Behari, Alejandro Soto-Gutierrez, Albert Gough, D Lansing Taylor, Mark E Schurdak
    Citation
    Cell Rep Methods . 2025 Apr 21;5(4):101028. doi: 10.1016/j.crmeth.2025.101028.
    Journal
    Link to Journal

  • Comparison of PNPLA3 Variants in a Biomimetic Liver System for Precision Therapy of Steatotic Liver Disease

    Category
    Title
    Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy.
    Date
    April 30, 2024
    Authors
    Xia M, Varmazyad M, Pla-Palacín I, Gavlock DC, DeBiasio R, LaRocca G, Reese C, Florentino RM, Faccioli LAP, Brown JA, Vernetti LA, Schurdak M, Stern AM, Gough A, Behari J, Soto-Gutierrez A, Taylor DL and Miedel MT
    Citation
    Cell Dev. Biol. 12:1423936. doi: 10.3389/fcell.2024.1423936
    Journal
    Link to Journal

  • Coupled Liver-Pancreatic Islet MPS Model

    Category
    Title
    A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.
    Date
    April 30, 2024
    Authors
    Aleman J, Ravikumar K, Wiegand C, Schurdak ME, Vernetti L, Gavlock D, Reese C, DeBiasio R, LaRocca G, Angarita YD, Gough A, Soto-Gutierrez A, Behari J, Yechoor V, Miedel MT, Stern AM, Banerjee I, Taylor DL
    Citation
    Commun Biol 7, 1317. 10.1038/s42003-024-07006-7
    Journal
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  • Quantitative Systems Pharmacology Platform for NAFLD Targeting Strategies

    Category
    Title
    A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies
    Date
    June 24, 2022
    Authors
    Lefever DE, Miedel MT, Pei F, DiStefano JK, Debiasio R, Shun TY, Saydmohammed M, Chikina M, Vernetti LA, Soto-Gutierrez A, Monga SP, Bataller R, Behari J, Yechoor VK, Bahar I, Gough A, Stern AM, Taylor DL
    Citation
    Metabolites. 2022;12(6). doi: 10.3390/metabo12060528. PubMed PMID: 35736460; PMCID: PMC9227696.
    Journal
    Link to Journal

  • Predicting Hepatic Drug Clearance Using a Four-Cell Liver Microphysiology System

    Category
    Title
    Prediction of Hepatic Drug Clearance with a Human Microfluidic Four-Cell Liver Acinus Microphysiology System
    Date
    September 21, 2021
    Authors
    Sakolish C, Luo YS, Valdiviezo A, Vernetti LA, Rusyn I, Chiu WA.
    Citation
    Toxicology. 2021;463:152954. doi: 10.1016/j.tox.2021.152954. PubMed PMID: 34543702; PMCID: PMC8585690.
    Journal
    Link to Journal

  • Tracking NAFLD Progression in Biomimetic Liver Systems Using Biosensors

    Category
    Title
    Quantifying the Progression of Non-Alcoholic Fatty Liver Disease in Human Biomimetic Liver Microphysiology Systems with Fluorescent Protein Biosensors
    Date
    May 08, 2021
    Authors
    Saydmohammed M, Jha A, Mahajan V, Gavlock D, Shun TY, DeBiasio R, Lefever D, Li X, Reese C, Kershaw EE, Yechoor V, Behari J, Soto-Gutierrez A, Vernetti L, Stern A, Gough A, Miedel MT, Lansing Taylor D.
    Citation
    Experimental Biology and Medicine. 2021;246:2420-41. doi: 10.1177/15353702211009228. PubMed PMID: 33957803.
    Journal
    Link to Journal

  • Reproducibility and Robustness of a Four-Cell Liver Acinus Microphysiology System (LAMPS)

    Category
    Title
    Analysis of Reproducibility and Robustness of a Human Microfluidic Four-Cell Liver Acinus Microphysiology System (LAMPS)
    Date
    2021 (Epub 2020-12-12)
    Authors
    Sakolish C, Reese CE, Luo YS, Valdiviezo A, Schurdak ME, Gough A, Taylor DL, Chiu WA, Vernetti LA, Rusyn I.
    Citation
    Toxicology. 2021;448:152651. doi: 10.1016/j.tox.2020.152651. PubMed PMID: 33307106; PMCID: PMC7785655.
    Journal
    Link to Journal

  • Human biomimetic liver microphysiology systems (MPS)

    Category
    Title
    Human biomimetic liver microphysiology systems in drug development and precision medicine.
    Date
    December 19, 2020
    Authors
    Gough A, Soto-Gutierrez A, Vernetti L, Ebrahimkhani MR, Stern AM, Taylor DL
    Citation
    Nat Rev Gastroenterol Hepatol. 2020. Epub 2020/12/19. doi: 10.1038/s41575-020-00386-1. PubMed PMID: 33335282.
    Journal
    Link to Journal

  • Harnessing Microphysiology Systems for Quantitative Pharmacology Models

    Category
    Title
    Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology
    Date
    2019
    Authors
    Taylor DL, Gough A, Schurdak ME, Vernetti L, Chennubhotla CS, Lefever D, Pei F, Faeder JR, Lezon TR, Stern AM, Bahar I
    Citation
    Handbook of Experimental Pharmacology: Springer; 2019. pp. 327-67.
    Journal
    Link to Journal
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